Endocrine Abstracts

Somatostatin is a ubiquitous neuropeptidic inhibitor of various cellular functions including endocrine and exocrine secretion. Moreover, this peptide may control cell proliferation in normal and tumoral tissues. Somatostatin biological effects are mediated by five subtype of G protein-coupled receptor, sst1 through sst5. The somatostatin analogs have high affinity for sst2 receptor and the success of in vivo peptide therapy is correlated with high levels of sst2 in th...